Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents

Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side by side comparative studies of thes...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Thiabaud, Grégory, He, Guangan, Sen, Sajal, Shelton, Kathryn A., Baze, Wallace B., Segura, Luke, Alaniz, Julie, Munoz Macias, Ruben, Lyness, Greg, Watts, Alan B., Kim, Hyun Min, Lee, Hyunseung, Cho, Mi Young, Hong, Kwan Soo, Finch, Rick, Siddik, Zahid H., Arambula, Jonathan F., Sessler, Jonathan L.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Physical Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132275/
https://ncbi.nlm.nih.gov/pubmed/32179677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914911117
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