Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents

Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side by side comparative studies of thes...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Thiabaud, Grégory, He, Guangan, Sen, Sajal, Shelton, Kathryn A., Baze, Wallace B., Segura, Luke, Alaniz, Julie, Munoz Macias, Ruben, Lyness, Greg, Watts, Alan B., Kim, Hyun Min, Lee, Hyunseung, Cho, Mi Young, Hong, Kwan Soo, Finch, Rick, Siddik, Zahid H., Arambula, Jonathan F., Sessler, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132275/
https://ncbi.nlm.nih.gov/pubmed/32179677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914911117
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