Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents

Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable of overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side by side comparative studies of thes...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Thiabaud, Grégory, He, Guangan, Sen, Sajal, Shelton, Kathryn A., Baze, Wallace B., Segura, Luke, Alaniz, Julie, Munoz Macias, Ruben, Lyness, Greg, Watts, Alan B., Kim, Hyun Min, Lee, Hyunseung, Cho, Mi Young, Hong, Kwan Soo, Finch, Rick, Siddik, Zahid H., Arambula, Jonathan F., Sessler, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Physical Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132275/
https://ncbi.nlm.nih.gov/pubmed/32179677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914911117
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