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A texaphyrin–oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells()

A texaphyrin–oxaliplatin conjugate, oxaliTEX, was designed to test the concept that a platinum analog can overcome defects in drug accumulation and p53-dependent DNA damage response in a tumor model expressing multifactorial mechanisms of cisplatin resistance. Cytotoxic studies resulted in a resista...

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Detalhes bibliográficos
Main Authors: Arambula, Jonathan F., Sessler, Jonathan L., Siddik, Zahid H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3737007/
https://ncbi.nlm.nih.gov/pubmed/23936624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD20206A
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