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The Iterative Gramicidin S Thioesterase Catalyzes Peptide Ligation and Cyclization
Here, we present a comprehensive in vitro characterization of the excised iterative, bimodular PCP-TE of the gramicidin S synthetase GrsB, which is able to act both as a ligation and a cyclization catalyst. Using the native pentapeptidyl-thioester substrates, GrsB PCP-TE catalyzes the dimerization a...
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| Udgivet i: | Chem Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Ltd.
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7129787/ https://ncbi.nlm.nih.gov/pubmed/17254948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.10.011 |
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