Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases

Nonribosomal peptide synthetases (NRPSs) assemble structurally complex peptides from simple building blocks such as amino and carboxyl acids. Product release by macrocyclization or hydrolysis is catalyzed by a thioesterase domain that is an integrated part of the NRPS enzyme. A second thioesterase o...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Schwarzer, Dirk, Mootz, Henning D., Linne, Uwe, Marahiel, Mohamed A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384573/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212382199
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