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Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases

Nonribosomal peptide synthetases (NRPSs) assemble structurally complex peptides from simple building blocks such as amino and carboxyl acids. Product release by macrocyclization or hydrolysis is catalyzed by a thioesterase domain that is an integrated part of the NRPS enzyme. A second thioesterase o...

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Bibliografske podrobnosti
Main Authors: Schwarzer, Dirk, Mootz, Henning D., Linne, Uwe, Marahiel, Mohamed A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC137840/
https://ncbi.nlm.nih.gov/pubmed/12384573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212382199
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