Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases

Nonribosomal peptide synthetases (NRPSs) assemble structurally complex peptides from simple building blocks such as amino and carboxyl acids. Product release by macrocyclization or hydrolysis is catalyzed by a thioesterase domain that is an integrated part of the NRPS enzyme. A second thioesterase o...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schwarzer, Dirk, Mootz, Henning D., Linne, Uwe, Marahiel, Mohamed A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12384573/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.212382199
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