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The Iterative Gramicidin S Thioesterase Catalyzes Peptide Ligation and Cyclization

Here, we present a comprehensive in vitro characterization of the excised iterative, bimodular PCP-TE of the gramicidin S synthetase GrsB, which is able to act both as a ligation and a cyclization catalyst. Using the native pentapeptidyl-thioester substrates, GrsB PCP-TE catalyzes the dimerization a...

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Publicat a:Chem Biol
Autors principals: Hoyer, Katharina M., Mahlert, Christoph, Marahiel, Mohamed A.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Ltd. 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7129787/
https://ncbi.nlm.nih.gov/pubmed/17254948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.10.011
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