Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain

The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to phosphoinositide metabolism and inhibits MyD88-directed signal transduction. BCAP is recruited to the TLR signalosome forming multitypic interactions...

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Foilsithe in:J Immunol
Main Authors: Lauenstein, Johannes U., Scherm, Michael J., Udgata, Atul, Moncrieffe, Martin C., Fisher, David I., Gay, Nicholas J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: AAI 2020
Ábhair:
Molecular and Structural Immunology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7128310/
https://ncbi.nlm.nih.gov/pubmed/32198144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901210
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