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Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand Binding
TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicator of viral infection. The extracellular domain of TLR3 dimerizes when it binds dsRNA, and the crystal structure of the dimeric complex reveals three sites of interaction on each extracellular domain, two that bind dsRNA and one that is r...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978612/ https://ncbi.nlm.nih.gov/pubmed/20861016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167973 |
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