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Dimerization of Toll-like Receptor 3 (TLR3) Is Required for Ligand Binding

TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicator of viral infection. The extracellular domain of TLR3 dimerizes when it binds dsRNA, and the crystal structure of the dimeric complex reveals three sites of interaction on each extracellular domain, two that bind dsRNA and one that is r...

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Bibliografiset tiedot
Päätekijät: Wang, Yan, Liu, Lin, Davies, David R., Segal, David M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978612/
https://ncbi.nlm.nih.gov/pubmed/20861016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.167973
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