DUAL OXIDASE-INDUCED SUSTAINED GENERATION OF HYDROGEN PEROXIDE CONTRIBUTES TO PHARMACOLOGICAL ASCORBATE-INDUCED CYTOTOXICITY

Pharmacological ascorbate treatment (P-AscH(−), high-dose, intravenous vitamin C) results in a transient short-term increase in the flux of hydrogen peroxide that is preferentially cytotoxic to cancer cells vs. normal cells. This study examines whether an increase in hydrogen peroxide is sustained p...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Gibson, Adrienne R., O’Leary, Brianne R., Du, Juan, Sarsour, Ehab H., Kalen, Amanda L., Wagner, Brett A., Stolwijk, Jeffrey M, Falls-Hubert, Kelly C., Alexander, Matthew S., Carroll, Rory S., Spitz, Douglas R., Buettner, Garry R., Goswami, Prabhat C., Cullen, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127976/
https://ncbi.nlm.nih.gov/pubmed/32041838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3094
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