DUAL OXIDASE-INDUCED SUSTAINED GENERATION OF HYDROGEN PEROXIDE CONTRIBUTES TO PHARMACOLOGICAL ASCORBATE-INDUCED CYTOTOXICITY

Pharmacological ascorbate treatment (P-AscH(−), high-dose, intravenous vitamin C) results in a transient short-term increase in the flux of hydrogen peroxide that is preferentially cytotoxic to cancer cells vs. normal cells. This study examines whether an increase in hydrogen peroxide is sustained p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Res
Prif Awduron: Gibson, Adrienne R., O’Leary, Brianne R., Du, Juan, Sarsour, Ehab H., Kalen, Amanda L., Wagner, Brett A., Stolwijk, Jeffrey M, Falls-Hubert, Kelly C., Alexander, Matthew S., Carroll, Rory S., Spitz, Douglas R., Buettner, Garry R., Goswami, Prabhat C., Cullen, Joseph J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127976/
https://ncbi.nlm.nih.gov/pubmed/32041838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3094
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