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Inhibition of BCL2 family members increases the efficacy of copper chelation in BRAF(V600E)-driven melanoma
The principal unmet need in BRAF(V600E)-positive melanoma is lack of an adequate therapeutic strategy capable of overcoming resistance to clinically approved targeted therapies against oncogenic BRAF and/or the downstream MEK1/2 kinases. We previously discovered that copper (Cu) is required for MEK1...
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| Pubblicato in: | Cancer Res |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7127963/ https://ncbi.nlm.nih.gov/pubmed/32005716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1784 |
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