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Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

We describe here the design, synthesis and biological evaluation of a series of molecules toward the development of novel peptidomimetic inhibitors of SARS-CoV 3CL(pro). A docking study involving binding between the initial lead compound 1 and the SARS-CoV 3CL(pro) motivated the replacement of a thi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Bioorg Med Chem
मुख्य लेखकों: Konno, Sho, Thanigaimalai, Pillaiyar, Yamamoto, Takehito, Nakada, Kiyohiko, Kakiuchi, Rie, Takayama, Kentaro, Yamazaki, Yuri, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Freire, Ernesto, Hayashi, Yoshio
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier Ltd. 2013
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127713/
https://ncbi.nlm.nih.gov/pubmed/23245752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.11.017
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