Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

We describe here the design, synthesis and biological evaluation of a series of molecules toward the development of novel peptidomimetic inhibitors of SARS-CoV 3CL(pro). A docking study involving binding between the initial lead compound 1 and the SARS-CoV 3CL(pro) motivated the replacement of a thi...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Konno, Sho, Thanigaimalai, Pillaiyar, Yamamoto, Takehito, Nakada, Kiyohiko, Kakiuchi, Rie, Takayama, Kentaro, Yamazaki, Yuri, Yakushiji, Fumika, Akaji, Kenichi, Kiso, Yoshiaki, Kawasaki, Yuko, Chen, Shen-En, Freire, Ernesto, Hayashi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127713/
https://ncbi.nlm.nih.gov/pubmed/23245752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.11.017
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