Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

We report on an extensive structure–activity relationship study of novel PI4K IIIβ inhibitors. The purine derivative of the potent screening hit T-00127-HEV1 has served as a suitable starting point for a thorough investigation of positions 8 and 2. While position 8 of the purine scaffold can only be...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Šála, Michal, Kögler, Martin, Plačková, Pavla, Mejdrová, Ivana, Hřebabecký, Hubert, Procházková, Eliška, Strunin, Dmytro, Lee, Gary, Birkus, Gabriel, Weber, Jan, Mertlíková-Kaiserová, Helena, Nencka, Radim
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Ltd. 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127540/
https://ncbi.nlm.nih.gov/pubmed/27090557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.04.002
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