Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof

HCMV infection represents a life-threatening condition for immunocompromised patients and newborn infants and novel anti-HCMV agents are clearly needed. In this regard, a series of 1-[ω-(phenoxy)alkyl]uracil derivatives were synthesized and examined for antiviral properties. Compounds 17, 20, 24 and...

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Détails bibliographiques
Publié dans:Bioorg Med Chem
Auteurs principaux: Novikov, Mikhail S., Babkov, Denis A., Paramonova, Maria P., Khandazhinskaya, Anastasia L., Ozerov, Alexander A., Chizhov, Alexander O., Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.
Format: Artigo
Langue:Inglês
Publié: Elsevier Ltd. 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7127185/
https://ncbi.nlm.nih.gov/pubmed/23743443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.05.009
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