N(1),N(3)-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase

A series of phenyloxyethyl and cinnamyl derivatives of substituted uracils were synthesized and found to exhibit potent activity against HIV-RT and HIV replication in cell culture. In general, the cinnamyl derivatives proved superior to the phenyloxyethyl derivatives, however 1-[2-(4-methylphenoxy)e...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Novikov, Mikhail S., Valuev-Elliston, Vladimir T., Babkov, Denis A., Paramonova, Maria P., Ivanov, Alexander V., Gavryushov, Sergey A, Khandazhinskaya, Anastasia L., Kochetkov, Sergey N., Pannecouque, Christophe, Andrei, Graciela, Snoeck, Robert, Balzarini, Jan, Seley-Radtke, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125863/
https://ncbi.nlm.nih.gov/pubmed/23357038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.027
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