Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

A series of 1′-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R = CN was...

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Détails bibliographiques
Publié dans:Bioorg Med Chem Lett
Auteurs principaux: Cho, Aesop, Saunders, Oliver L., Butler, Thomas, Zhang, Lijun, Xu, Jie, Vela, Jennifer E., Feng, Joy Y., Ray, Adrian S., Kim, Choung U.
Format: Artigo
Langue:Inglês
Publié: Elsevier Ltd. 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126871/
https://ncbi.nlm.nih.gov/pubmed/22446091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.02.105
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