Foot-and-mouth disease virus induces lysosomal degradation of host protein kinase PKR by 3C proteinase to facilitate virus replication

The interferon-induced double-strand RNA activated protein kinase (PKR) plays important roles in host defense against viral infection. Here we demonstrate the significant antiviral role of PKR against foot-and-mouth disease virus (FMDV) and report that FMDV infection inhibits PKR expression and acti...

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Publicado no:Virology
Main Authors: Li, Chuntian, Zhu, Zixiang, Du, Xiaoli, Cao, Weijun, Yang, Fan, Zhang, Xiangle, Feng, Huanhuan, Li, Dan, Zhang, Keshan, Liu, Xiangtao, Zheng, Haixue
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126777/
https://ncbi.nlm.nih.gov/pubmed/28662438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.06.023
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