Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication

The role of the innate immune protein LGP2 (laboratory of genetics and physiology 2) in FMDV-infected cells remains unknown. Here, we demonstrate the antiviral role of LGP2 during FMDV infection. FMDV infection triggered LGP2 mRNA expression but reduced protein expression. Overexpression of LGP2 sup...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhu, Zixiang, Li, Chuntian, Du, Xiaoli, Wang, Guoqing, Cao, Weijun, Yang, Fan, Feng, Huanhuan, Zhang, Xiangle, Shi, Zhengwang, Liu, Huanan, Tian, Hong, Li, Dan, Zhang, Keshan, Liu, Xiangtao, Zheng, Haixue
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477588/
https://ncbi.nlm.nih.gov/pubmed/28406479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.170
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