Foot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication

The role of the innate immune protein LGP2 (laboratory of genetics and physiology 2) in FMDV-infected cells remains unknown. Here, we demonstrate the antiviral role of LGP2 during FMDV infection. FMDV infection triggered LGP2 mRNA expression but reduced protein expression. Overexpression of LGP2 sup...

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Foilsithe in:Cell Death Dis
Main Authors: Zhu, Zixiang, Li, Chuntian, Du, Xiaoli, Wang, Guoqing, Cao, Weijun, Yang, Fan, Feng, Huanhuan, Zhang, Xiangle, Shi, Zhengwang, Liu, Huanan, Tian, Hong, Li, Dan, Zhang, Keshan, Liu, Xiangtao, Zheng, Haixue
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2017
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477588/
https://ncbi.nlm.nih.gov/pubmed/28406479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.170
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