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New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity
New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alkoxyalkyl esters, amino acid phosphoramidates and/or tyrosine. The activity...
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| Udgivet i: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier Ltd.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7126465/ https://ncbi.nlm.nih.gov/pubmed/28757102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.06.046 |
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