Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2-pyrazinecarboxamide, 1,2,4-triazole-3-carboxamide or 4-substituted-1,2,3-triazoles were prepared in a straight approach through a...

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Publicado en:Eur J Med Chem
Autores principales: Hamada, Manabu, Roy, Vincent, McBrayer, Tamara R., Whitaker, Tony, Urbina-Blanco, Cesar, Nolan, Steven P., Balzarini, Jan, Snoeck, Robert, Andrei, Graciela, Schinazi, Raymond F., Agrofoglio, Luigi A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier Masson SAS. Published by Elsevier Masson SAS 2013
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111275/
https://ncbi.nlm.nih.gov/pubmed/23911854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2013.06.053
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