New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity

New 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine (PMEO-DAPy) and 1-[2-(phosphonomethoxy)ethyl]-5-azacytosine (PME-5-azaC) prodrugs were prepared with a pro-moiety consisting of carbonyloxymethyl esters (POM, POC), alkoxyalkyl esters, amino acid phosphoramidates and/or tyrosine. The activity...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem
Main Authors: Krečmerová, Marcela, Dračínský, Martin, Snoeck, Robert, Balzarini, Jan, Pomeisl, Karel, Andrei, Graciela
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Ltd. 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126465/
https://ncbi.nlm.nih.gov/pubmed/28757102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.06.046
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