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The quaternary assembly of KRas4B with Raf-1 at the membrane
Proximally located in the membrane, oncogenic Ras dimers (or nanoclusters) can recruit and promote Raf dimerization and MAPK (Raf/MEK/ERK) signaling. Among Ras isoforms, KRas4B is the most frequently mutated. Recent data on the binary KRas4B–Raf-1 complex suggested that Raf-1 CRD not only executes m...
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| Publicado no: | Comput Struct Biotechnol J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Research Network of Computational and Structural Biotechnology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7125320/ https://ncbi.nlm.nih.gov/pubmed/32257057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2020.03.018 |
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