The mechanism of activation of monomeric B-Raf V600E

Oncogenic mutations in the serine/threonine kinase B-Raf, particularly the V600E mutation, are frequent in cancer, making it a major drug target. Although much is known about B-Raf’s active and inactive states, questions remain about the mechanism by which the protein changes between these two state...

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Библиографические подробности
Опубликовано в: :Comput Struct Biotechnol J
Главные авторы: Maloney, Ryan C., Zhang, Mingzhen, Jang, Hyunbum, Nussinov, Ruth
Формат: Artigo
Язык:Inglês
Опубликовано: Research Network of Computational and Structural Biotechnology 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8215184/
https://ncbi.nlm.nih.gov/pubmed/34188782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.06.007
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