Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension

Environmental and epigenetic factors often play an important role in polygenic disorders. However, how such factors affect disease-specific tissues at the molecular level remains to be understood. Here, we address this in pulmonary arterial hypertension (PAH). We obtain pulmonary arterial endothelia...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Reyes-Palomares, Armando, Gu, Mingxia, Grubert, Fabian, Berest, Ivan, Sa, Silin, Kasowski, Maya, Arnold, Christian, Shuai, Mao, Srivas, Rohith, Miao, Simon, Li, Dan, Snyder, Michael P., Rabinovitch, Marlene, Zaugg, Judith B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125148/
https://ncbi.nlm.nih.gov/pubmed/32245974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15463-x
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