Genetic Control of Chromatin States in Humans Involves Local and Distal Chromosomal Interactions

Deciphering the impact of genetic variants on gene regulation is fundamental to understanding human disease. Although gene regulation often involves long-range interactions, it is unknown to what extent non-coding genetic variants influence distal molecular phenotypes. Here, we integrate chromatin p...

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Publicado no:Cell
Main Authors: Grubert, Fabian, Zaugg, Judith B., Kasowski, Maya, Ursu, Oana, Spacek, Damek V., Martin, Alicia R., Greenside, Peyton, Srivas, Rohith, Phanstiel, Doug H., Pekowska, Aleksandra, Heidari, Nastaran, Euskirchen, Ghia, Huber, Wolfgang, Pritchard, Jonathan K., Bustamante, Carlos D., Steinmetz, Lars M., Kundaje, Anshul, Snyder, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556133/
https://ncbi.nlm.nih.gov/pubmed/26300125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.07.048
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