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The Discovery and Development of Daclatasvir: An Inhibitor of the Hepatitis C Virus NS5A Replication Complex

The discovery of the hepatitis C virus (HCV) NS5A replication inhibitor daclatasvir (1) had its origins in a phenotypic screening lead. However, during the optimization campaign, it was observed that some members of the chemotype underwent a radical dimerization under the assay conditions. This redi...

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Bibliographische Detailangaben
Veröffentlicht in:HCV: The Journey from Discovery to a Cure
Hauptverfasser: Meanwell, Nicholas A., Belema, Makonen
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7122418/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/7355_2018_47
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