Identification of Hepatitis C Virus NS5A Inhibitors

Using a cell-based replicon screen, we identified a class of compounds with a thiazolidinone core structure as inhibitors of hepatitis C virus (HCV) replication. The concentration of one such compound, BMS-824, that resulted in a 50% inhibition of HCV replicon replication was ∼5 nM, with a therapeut...

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Detalhes bibliográficos
Main Authors: Lemm, Julie A., O'Boyle, Donald, Liu, Mengping, Nower, Peter T., Colonno, Richard, Deshpande, Milind S., Snyder, Lawrence B., Martin, Scott W., St. Laurent, Denis R., Serrano-Wu, Michael H., Romine, Jeffrey L., Meanwell, Nicholas A., Gao, Min
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798423/
https://ncbi.nlm.nih.gov/pubmed/19812153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01360-09
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