Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

[Image: see text] The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, which revealed that inhibitory activ...

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Autores principales: Romine, Jeffrey L., St. Laurent, Denis R., Leet, John E., Martin, Scott W., Serrano-Wu, Michael H., Yang, Fukang, Gao, Min, O’Boyle, Donald R, Lemm, Julie A., Sun, Jin-Hua, Nower, Peter T., Huang, Xiaohua (Stella), Deshpande, Milind S., Meanwell, Nicholas A., Snyder, Lawrence B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2011
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017990/
https://ncbi.nlm.nih.gov/pubmed/24900306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1002647
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