Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis

Deregulated overexpression of MYC is implicated in the development and malignant progression of most (∼70%) human tumors. MYC drives cell growth and proliferation, but also, at high levels, promotes apoptosis. Here, we report that the proliferative capacity of MYC-driven normal and neoplastic B lymp...

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Vydáno v:Blood
Hlavní autoři: Nguyen, Hai Vu, Vandenberg, Cassandra J., Ng, Ashley P., Robati, Mikara R., Anstee, Natasha S., Rimes, Joel, Hawkins, Edwin D., Cory, Suzanne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2020
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118401/
https://ncbi.nlm.nih.gov/pubmed/31978211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003014
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