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Microglial Depletion with CSF1R Inhibitor During Chronic Phase of Experimental Traumatic Brain Injury Reduces Neurodegeneration and Neurological Deficits

Chronic neuroinflammation with sustained microglial activation occurs following severe traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and neurological deficits. Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Henry, Rebecca J., Ritzel, Rodney M., Barrett, James P., Doran, Sarah J., Jiao, Yun, Leach, Jennie B., Szeto, Gregory L., Wu, Junfang, Stoica, Bogdan A., Faden, Alan I., Loane, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7117897/
https://ncbi.nlm.nih.gov/pubmed/32094203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2402-19.2020
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