Old age increases microglial senescence, exacerbates secondary neuroinflammation, and worsens neurological outcomes following acute traumatic brain injury in mice.

Following traumatic brain injury (TBI), individuals over 65 years of age show increased mortality and worse functional outcomes compared to younger persons. As neuroinflammation is a key pathobiological mechanism of secondary injury after TBI, we examined how aging affects posttraumatic microglial r...

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Bibliografiset tiedot
Julkaisussa:Neurobiol Aging
Päätekijät: Ritzel, Rodney M., Doran, Sarah J., Glaser, Ethan P., Meadows, Victoria E., Faden, Alan I., Stoica, Bogdan A., Loane, David J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6486858/
https://ncbi.nlm.nih.gov/pubmed/30904769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2019.02.010
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