Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB

The mutagenic APOBEC3B (A3B) cytosine deaminase is frequently over-expressed in cancer and promotes tumour heterogeneity and therapy resistance. Hence, understanding the mechanisms that underlie A3B over-expression is important, especially for developing therapeutic approaches to reducing A3B levels...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Periyasamy, Manikandan, Singh, Anup K, Gemma, Carolina, Farzan, Raed, Allsopp, Rebecca C, Shaw, Jacqueline A, Charmsaz, Sara, Young, Leonie S, Cunnea, Paula, Coombes, R Charles, Győrffy, Balázs, Buluwela, Lakjaya, Ali, Simak
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116738/
https://ncbi.nlm.nih.gov/pubmed/33323971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01583-7
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