p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

Cancer genome sequencing has implicated the cytosine deaminase activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC) genes as an important source of mutations in diverse cancers, with APOBEC3B (A3B) expression especially correlated with such cancer mutations. To better...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Periyasamy, Manikandan, Singh, Anup K., Gemma, Carolina, Kranjec, Christian, Farzan, Raed, Leach, Damien A., Navaratnam, Naveenan, Pálinkás, Hajnalka L., Vértessy, Beata G., Fenton, Tim R., Doorbar, John, Fuller-Pace, Frances, Meek, David W., Coombes, R. Charles, Buluwela, Laki, Ali, Simak
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737468/
https://ncbi.nlm.nih.gov/pubmed/28977491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx721
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