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Regulation and Function of the PD-L1 Checkpoint
Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor immunity by counteracting T cell-activating signals. Antibody-based PD-1-PD-L1 inhibitors can induce durable tumor remissions in pat...
Guardat en:
| Publicat a: | Immunity |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7116507/ https://ncbi.nlm.nih.gov/pubmed/29562194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.03.014 |
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