Adipose PD-L1 Modulates PD-1/PD-L1 Checkpoint Blockade Immunotherapy Efficacy in Breast Cancer

Programmed death-ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) modulate antitumor immunity and are major targets of checkpoint blockade immunotherapy. However, clinical trials of anti-PD-L1 and anti-PD-1 antibodies in breast cancer demonstrate only modest efficacy. Further...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Wu, Bogang, Sun, Xiujie, Gupta, Harshita B., Yuan, Bin, Li, Jingwei, Ge, Fei, Chiang, Huai-Chin, Zhang, Xiaowen, Zhang, Chi, Zhang, Deyi, Yang, Jing, Hu, Yanfen, Curiel, Tyler J., Li, Rong
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209395/
https://ncbi.nlm.nih.gov/pubmed/30393583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1500107
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