Intracerebral delivery of small interfering RNAs (siRNAs) using adenoviral vector protects mice against lethal peripheral rabies challenge

To investigate the potential of RNA interference (RNAi) as antiviral agent against rabies, two small interfering RNAs (siRNAs) targeting rabies virus (RABV) nucleoprotein (N) and polymerase (L) genes were designed and evaluated. Both siRNAs knockdown or silenced the target RABV genes as evaluated in...

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Bibliografiska uppgifter
I publikationen:Virus Res
Huvudupphovsmän: Gupta, Praveen K., Sonwane, Arvind A., Singh, Niraj K., Meshram, Chetan D., Dahiya, Shyam S., Pawar, Sachin S., Gupta, Swatantra P., Chaturvedi, V.K., Saini, Mohini
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier B.V. 2012
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114402/
https://ncbi.nlm.nih.gov/pubmed/21864591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2011.08.004
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