Intracerebral delivery of small interfering RNAs (siRNAs) using adenoviral vector protects mice against lethal peripheral rabies challenge

To investigate the potential of RNA interference (RNAi) as antiviral agent against rabies, two small interfering RNAs (siRNAs) targeting rabies virus (RABV) nucleoprotein (N) and polymerase (L) genes were designed and evaluated. Both siRNAs knockdown or silenced the target RABV genes as evaluated in...

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Udgivet i:Virus Res
Main Authors: Gupta, Praveen K., Sonwane, Arvind A., Singh, Niraj K., Meshram, Chetan D., Dahiya, Shyam S., Pawar, Sachin S., Gupta, Swatantra P., Chaturvedi, V.K., Saini, Mohini
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier B.V. 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114402/
https://ncbi.nlm.nih.gov/pubmed/21864591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virusres.2011.08.004
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