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Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers()
Two-pore channels (TPCs) are Ca(2+)-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including viruses. As a result, TPCs are emerging as important drug targets. However, their pharmacology is ill-defined. There are no approved drugs to...
שמור ב:
| הוצא לאור ב: | Biochim Biophys Acta Mol Cell Res |
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| Main Authors: | , , , , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Published by Elsevier B.V.
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7114365/ https://ncbi.nlm.nih.gov/pubmed/30408544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2018.10.022 |
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