Mining of Ebola virus entry inhibitors identifies approved drugs as two-pore channel pore blockers()

Two-pore channels (TPCs) are Ca(2+)-permeable ion channels localised to the endo-lysosomal system where they regulate trafficking of various cargoes including viruses. As a result, TPCs are emerging as important drug targets. However, their pharmacology is ill-defined. There are no approved drugs to...

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Foilsithe in:Biochim Biophys Acta Mol Cell Res
Main Authors: Penny, Christopher J., Vassileva, Kristin, Jha, Archana, Yuan, Yu, Chee, Xavier, Yates, Elizabeth, Mazzon, Michela, Kilpatrick, Bethan S., Muallem, Shmuel, Marsh, Mark, Rahman, Taufiq, Patel, Sandip
Formáid: Artigo
Teanga:Inglês
Foilsithe: Published by Elsevier B.V. 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7114365/
https://ncbi.nlm.nih.gov/pubmed/30408544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2018.10.022
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