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Convergent regulation of the lysosomal two-pore channel-2 by Mg(2+), NAADP, PI(3,5)P(2) and multiple protein kinases
Lysosomal Ca(2+) homeostasis is implicated in disease and controls many lysosomal functions. A key in understanding lysosomal Ca(2+) signaling was the discovery of the two-pore channels (TPCs) and their potential activation by NAADP. Recent work concluded that the TPCs function as a PI(3,5)P(2) acti...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989630/ https://ncbi.nlm.nih.gov/pubmed/24502975 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201387035 |
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