Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface

The PB1 C-terminal domain and PB2 N-terminal domain interaction of the influenza A polymerase, which modulates the assembly of PB1 and PB2 subunits, may serve as a valuable target for the development of novel anti-influenza therapeutics. In this study, we performed a systematic screening of a chemic...

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發表在:Antiviral Res
Main Authors: Yuan, Shuofeng, Chu, Hin, Ye, Jiahui, Singh, Kailash, Ye, Ziwei, Zhao, Hanjun, Kao, Richard Y.T., Chow, Billy K.C., Zhou, Jie, Zheng, Bo-Jian
格式: Artigo
語言:Inglês
出版: Elsevier B.V. 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7113721/
https://ncbi.nlm.nih.gov/pubmed/27840201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2016.11.005
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