Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, which can dramatically increase during severe pandemic outbreaks. Antiviral drugs are an indispensable weapon to treat infected people and reduce the impact on human health, nevertheless anti-Flu armament...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Massari, Serena, Bertagnin, Chiara, Pismataro, Maria Chiara, Donnadio, Anna, Nannetti, Giulio, Felicetti, Tommaso, Di Bona, Stefano, Nizi, Maria Giulia, Tensi, Leonardo, Manfroni, Giuseppe, Loza, Maria Isabel, Sabatini, Stefano, Cecchetti, Violetta, Brea, Jose, Goracci, Laura, Loregian, Arianna, Tabarrini, Oriana
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Masson SAS. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561591/
https://ncbi.nlm.nih.gov/pubmed/33328103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2020.112944
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