From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Massari, Serena, Corona, Angela, Distinto, Simona, Desantis, Jenny, Caredda, Alessia, Sabatini, Stefano, Manfroni, Giuseppe, Felicetti, Tommaso, Cecchetti, Violetta, Pannecouque, Christophe, Maccioni, Elias, Tramontano, Enzo, Tabarrini, Oriana
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211256/
https://ncbi.nlm.nih.gov/pubmed/30362381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1523901
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