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Role of IFN-γ responsiveness in CD8 T cell-mediated viral clearance and demyelination in coronavirus-infected mice

Immunocompetent, but not RAG1(−/−) mice infected with MHV–JHM develop demyelination. Transferred CD8 T cell-enriched splenocytes reconstitute demyelination, and this ability is dependent on donor IFN-γ. We used IFN-γR1(−/−) mice to examine the target of IFN-γ in CD8 T cell-mediated demyelination. In...

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Detalhes bibliográficos
Publicado no:J Neuroimmunol
Main Authors: Templeton, Steven P., Perlman, Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7112937/
https://ncbi.nlm.nih.gov/pubmed/18082272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2007.10.030
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