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Efficient diastereoselective synthesis of a new class of azanucleosides: 2′-homoazanucleosides

Azanucleosides, sugar-modified nucleoside analogues containing a 4′ nitrogen atom, have shown a lot of therapeutic potential, e.g. as anti-cancer and antiviral agents. We report the synthesis of a series of 2’-homoazanucleosides, in which the nucleobase is attached to the 2’-position of the pyrrolid...

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Detalhes bibliográficos
Publicado no:Tetrahedron
Main Authors: Bouton, Jakob, Van Hecke, Kristof, Van Calenbergh, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7111761/
https://ncbi.nlm.nih.gov/pubmed/32287431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2017.05.083
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