Enantiomerically Pure Phosphonated Carbocyclic 2'-Oxa-3'-Azanucleosides: Synthesis and Biological Evaluation

Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (−)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]...

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Bibliographic Details
Published in:	Molecules
Main Authors:	Romeo, Roberto, Carnovale, Caterina, Giofrè, Salvatore V., Monciino, Giulia, Chiacchio, Maria A., Sanfilippo, Claudia, Macchi, Beatrice
Format:	Artigo
Language:	Inglês
Published:	MDPI 2014
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6270948/ https://ncbi.nlm.nih.gov/pubmed/25221866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules190914406
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Enantiomerically Pure Phosphonated Carbocyclic 2'-Oxa-3'-Azanucleosides: Synthesis and Biological Evaluation

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