Synthesis and Biological Evaluation of Pyrimidine-oxazolidin-2-arylimino Hybrid Molecules as Antibacterial Agents

Pyrimidine-1,3-oxazolidin-2-arylimino hybrids have been synthesized as a new class of antibacterial agents. The synthetic approach exploits a Cu(II)-catalyzed intramolecular halkoxyhalogenation of alkynyl ureas, followed by a Suzuki coupling reaction with 2,4-dimethoxypyrimidin-5-boronic acid. Biolo...

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Gepubliceerd in:Molecules
Hoofdauteurs: Romeo, Roberto, Chiacchio, Maria A., Campisi, Agata, Monciino, Giulia, Veltri, Lucia, Iannazzo, Daniela, Broggini, Gianluigi, Giofrè, Salvatore V.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099984/
https://ncbi.nlm.nih.gov/pubmed/30018259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23071754
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